Transformational Healthcare Leadership: Improving patient outcomes

'My advice is if you really have some important issues to solve, make sure you prioritise and be ruthless in your prioritisation.'

Mark O'Brien in conversation with Bruno Holthof

In episode 1 of our new podcast, Transformational Healthcare Leadership, Dr Mark O’Brien talks to Professor Bruno Holthof, a Visiting Professor of Health Innovation in the Nuffield Department of Medicine at Oxford University and an investment partner of the EQT Health Economics Fund.

Bruno is an incredibly experienced healthcare leader having spent nearly 40 years successfully straddling the scientific and management world. After qualifying in medicine Bruno went on to earn an MBA and then a PhD in Health Economics. He was a partner with McKinsey & Company and served a wide range of healthcare clients, gaining significant expertise in the areas of strategy, organisation and operations.

He later moved into an executive position, first as CEO at Antwerp Hospital Network (ZNA), where he transformed ZNA into the most profitable hospital group in Belgium, and then as CEO of Oxford University Hospitals (OUH) where he was involved in the development of the Oxford-AstraZeneca Covid-19 vaccine. He said one of the most important things that he did in both organisations was putting the right leaders in charge of each of the clinical services.


One of my passions is to improve outcome and lower the cost against the current golden standards of medicine.

Bruno is passionate about innovation in the healthcare industry and sees it as a key driver in improving patient outcomes. He is convinced that in the next 10 years the advances in genomics and artificial intelligence will translate into real benefits for individual patients and entire populations. Alongside his current role in the Nuffield Department of Medicine Bruno is a mentor on the Health Stream at the Creative Destruction Lab at Saïd Business School. 

In our Transformational Healthcare Leadership podcast we are talking to leaders from across the globe about the massive disruption in ‘business as usual’ healthcare caused by the Covid-19 pandemic, the depth of the workforce exhaustion, and the wave of technological and therapeutic innovations impacting the industry. Throughout this series we will be exploring the five key themes of our Oxford Healthcare Leadership Programme: 

  • the personal leadership journey
  • understanding the evolving environment
  • effective strategy formation
  • driving innovation
  • improving performance

Mark is the programme director and has worked in healthcare since the mid-1980s. He has a lifelong passion for improving the culture and quality of healthcare, and is confident the programme will bring together great minds to help foster lasting change and innovation.